Advil Cold & Flu coated Tablets are used to relieve nasal or sinus congestion with headache, fever and pain which are associated with the cold and flu. The medication contains ibuprofen which reduces inflammation, relieves pain and fever. It also contains pseudoephedrine hydrochloride, a decongestant, which clears the nasal passage. This medication should only be used if you have a blocked nose together with headache, pain and fever. Do not use it if you have only one of the symptoms.