E45 Cream has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. It's quickly and easily absorbed and works by replacing lost moisture and forming a protective barrier, leaving your skin feeling soft and comfortable again. Treatment for Dry Skin Conditions. Suitable for eczema, dermatitis, ichthyosis and psoriasis Clinically Proven & Dermatological tested.