Ready to use and with no need for refrigeration, each gel sheet stays in place and provides up to 8 hours of cooling relief. Kool n Soothe Migraine sheets can be removed easily without leaving any sticky residue. For best results Kool n Soothe Migraine should be used at the first sign of migraine and headache. Kool n Soothe – Whenever you eed the relief for cooling relief from: Headache High Temperature Hot Flushes Sprains To Relax